Actualités p53.html
Quand le nombre de chromosomes déraille 🧬
Mon, 10 Mar 2025 21:00:00 GMT
La mauvaise ségrégation des chromosomes lors de la division cellulaire entraîne des anomalies qui perturbent le ...
When the number of chromosomes goes off track
Mon, 10 Mar 2025 22:01:00 GMT
It results from errors in the segregation of chromosomes from the mother cell to the two daughter cells during mitosis, i.e., cell division, and leads to the activation of p53, a key protein that ...
The p53 and RB tumour-suppressor pathways
Thu, 08 Nov 2012 07:23:00 GMT
p53 and RB are at the heart of the two main tumour-suppressor pathways that control cellular responses to potentially oncogenic stimuli. Each pathway consists of several upstream regulators and ...
ATM: the p53 booster
Tue, 25 Jun 2024 14:14:00 GMT
The ATM gene (mutated in the disease ataxia telangiectasia) activates the p53 tumor suppressor protein in response to DNA damage, explaining the higher incidence of cancer in AT patients.
Carol Prives
Tue, 08 Oct 2024 13:09:00 GMT
Mutation of the p53 tumor suppressor gene is the most frequent lesion detected in cancer. Consequently, understanding the structure and function of the normal p53 protein and how it differs from the ...