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p53 : The Most Frequently Altered Gene in Human Cancers
Sat, 25 Nov 2023 13:58:00 GMT
p53 is a common denominator among human cancers. How was it discovered? What are the persistent questions about its function? Aa Aa Aa It seems nearly impossible for a normal cell to become a ...
p53 polymorphisms: cancer implications
Thu, 30 May 2024 02:59:00 GMT
p53 lies at the hub of a vast signalling network. Polymorphisms in upstream activators, repressors or downstream effectors of p53 might individually modulate cancer risk or interact with ...
Tumor suppressor forms gel-like assemblies to sacrifice cancer cells
Mon, 11 Nov 2024 08:47:00 GMT
There are processes in the human body that can suppress the growth and proliferation of cancer cells. These mechanisms, including those involving the tumor suppressor protein p53, are widely studied ...
Colon cancer risk linked to p53 gene in ulcerative colitis
Thu, 24 Oct 2024 17:00:00 GMT
Researchers in the lab of Michael Sigal at the Max Delbrück Center and Charité—Universitätsmedizin Berlin have elucidated the role of the p53 gene in ulcerative colitis. The study ...
The role of p53 in male infertility
Sat, 12 Oct 2024 17:01:00 GMT
The tumor suppressor p53 is a transcription factor involved in a variety of crucial cellular functions, including cell cycle arrest, DNA repair and apoptosis. Still, a growing number of studies ...
Cancer risk linked to an inflammatory bowel disease: Study reveals
Wed, 30 Oct 2024 01:16:00 GMT
The study emphasises on the role of the p53 tumor suppressor gene in the pathogenesis of ulcerative colitis - an inflammatory bowel disease.
tealeave/da-wei-lin-data
Fri, 20 May 2022 17:36:00 GMT
Tumor Suppressor Gene Reactivation: Developing novel approaches for directed drug design, especially in the development of small molecules to reactivate mutant p53 in human cancer. Proteomics & CRISPR ...
Diadem Unveils Novel Findings on Early Alzheimer's Disease Detection Using p53-Specific Antibody at CTAD 2024
Fri, 01 Nov 2024 00:38:00 GMT
Diadem SpA, in partnership with researchers from the University of Texas Medical Branch, led by Prof. Rakez Kayed from the Mitchell Center for Neurodegenerative Disorders, presented groundbreaking ...
Carol Prives
Tue, 08 Oct 2024 13:09:00 GMT
Mutation of the p53 tumor suppressor gene is the most frequent lesion detected in cancer. Consequently, understanding the structure and function of the normal p53 protein and how it differs from the ...
Covalent Modification of p53 by (E)-1-(4-Methylpiperazin-1-yl)-3-(5-nitrofuran-2-yl)prop-2-en-1-one
Sun, 13 Oct 2024 17:00:00 GMT
Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, United States ...
Natural Phycocyanin/Paclitaxel Micelle Delivery of Therapeutic P53 to Activate Apoptosis for HER2 or ER Positive Breast Cancer Therapy
Thu, 10 Oct 2024 17:00:00 GMT
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Diadem Unveils Novel Findings on Early Alzheimer's Disease Detection Using p53-Specific Antibody at CTAD 2024
Thu, 31 Oct 2024 17:00:00 GMT
The study focused on U-p53AZ, a conformational variant of the p53 protein linked to Alzheimer's disease (AD). Using a U-p53AZ-specific antibody developed by Diadem, the team identified the ...