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p53 polymorphisms: cancer implications
Thu, 30 May 2024 02:59:00 GMT
p53 lies at the hub of a vast signalling network. Polymorphisms in upstream activators, repressors or downstream effectors of p53 might individually modulate cancer risk or interact with ...
p53 : The Most Frequently Altered Gene in Human Cancers
Sat, 25 Nov 2023 13:58:00 GMT
p53 is a common denominator among human cancers. How was it discovered? What are the persistent questions about its function? Aa Aa Aa It seems nearly impossible for a normal cell to become a ...
The role of p53 in male infertility
Sat, 12 Oct 2024 17:01:00 GMT
The tumor suppressor p53 is a transcription factor involved in a variety of crucial cellular functions, including cell cycle arrest, DNA repair and apoptosis. Still, a growing number of studies ...
Tumor suppressor forms gel-like assemblies to sacrifice cancer cells
Mon, 11 Nov 2024 08:47:00 GMT
There are processes in the human body that can suppress the growth and proliferation of cancer cells. These mechanisms, including those involving the tumor suppressor protein p53, are widely studied ...
Colon cancer risk linked to p53 gene in ulcerative colitis
Thu, 24 Oct 2024 17:00:00 GMT
Researchers in the lab of Michael Sigal at the Max Delbrück Center and Charité—Universitätsmedizin Berlin have elucidated the role of the p53 gene in ulcerative colitis. The study ...
Foreign firms pledged to invest P146b in Q3—PSA
Thu, 14 Nov 2024 04:40:00 GMT
Foreign investment pledges surged 434 percent in the third quarter of 2024 to P146.75 billion from P27.46 billion in the same period last year. The ...
tealeave/da-wei-lin-data
Fri, 20 May 2022 17:36:00 GMT
Tumor Suppressor Gene Reactivation: Developing novel approaches for directed drug design, especially in the development of small molecules to reactivate mutant p53 in human cancer. Proteomics & CRISPR ...
Carol Prives
Tue, 08 Oct 2024 13:09:00 GMT
Mutation of the p53 tumor suppressor gene is the most frequent lesion detected in cancer. Consequently, understanding the structure and function of the normal p53 protein and how it differs from the ...
Diadem Unveils Novel Findings on Early Alzheimer's Disease Detection Using p53-Specific Antibody at CTAD 2024
Fri, 01 Nov 2024 00:38:00 GMT
Diadem SpA, in partnership with researchers from the University of Texas Medical Branch, led by Prof. Rakez Kayed from the Mitchell Center for Neurodegenerative Disorders, presented groundbreaking ...
Covalent Modification of p53 by (E)-1-(4-Methylpiperazin-1-yl)-3-(5-nitrofuran-2-yl)prop-2-en-1-one
Sun, 13 Oct 2024 17:00:00 GMT
Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, United States ...
Natural Phycocyanin/Paclitaxel Micelle Delivery of Therapeutic P53 to Activate Apoptosis for HER2 or ER Positive Breast Cancer Therapy
Thu, 10 Oct 2024 17:00:00 GMT
Get article recommendations from ACS based on references in your Mendeley library. Pair your accounts. Export articles to Mendeley Get article recommendations from ACS based on references in your ...
Cancer risk linked to p53 in ulcerative colitis: Study
Sun, 27 Oct 2024 19:12:00 GMT
A key role for p53: Ulcerative colitis affects the large intestine, specifically areas called "crypts," tube-like glands within the epithelial tissue that lines the intestine. Crypts contain stem ...