Actualités p53.html
p53 : The Most Frequently Altered Gene in Human Cancers
Sat, 25 Nov 2023 13:58:00 GMT
p53 is a common denominator among human cancers. How was it discovered? What are the persistent questions about its function? Aa Aa Aa It seems nearly impossible for a normal cell to become a ...
HTML5 Boilerplate
Sun, 22 Sep 2024 17:01:00 GMT
HTML5 Boilerplate est un modèle de projet open source pour la création de sites web rapides, robustes et adaptatifs. Il fournit une structure de base pour les sites web modernes avec des ...
Research points to potential new treatment for aggressive prostate cancer subtype
Fri, 04 Oct 2024 08:00:03 GMT
When researchers at the University of Michigan Rogel Cancer Center first identified a new subtype of aggressive prostate cancer, they knew they needed to understand how this genetic alteration was ...
Clasp Therapeutics to Present Preclinical Data Evaluating Novel T Cell Engager Targeting p53 Mutant Solid Tumors
Fri, 04 Oct 2024 06:38:00 GMT
Clasp Therapeutics, a biotechnology company bringing unparalleled precision to immuno-oncology using next-generation T cell engagers (TCEs), today announced it will present comprehensive preclinical ...
The p53 Tumor Suppressor Network
Thu, 23 Aug 2018 03:31:00 GMT
Our lab has had a long-standing interest in the role and regulation of the p53 tumor suppressor. Mutations in the p53 gene (TP53) are often associated with aggressive tumor behavior and poor patient ...
This Shark Can Live For More Than Four Human Lifetimes. Its DNA Could Finally Tell Us How.
Mon, 30 Sep 2024 05:00:00 GMT
The Greenland shark has by far the longest lifespan for a vertebrate, with an estimated life span of around 400 years. Scientists recently synthesized its genome to investigate what exactly ...
The p53 and RB tumour-suppressor pathways
Thu, 08 Nov 2012 07:23:00 GMT
p53 and RB are at the heart of the two main tumour-suppressor pathways that control cellular responses to potentially oncogenic stimuli. Each pathway consists of several upstream regulators and ...
jantimon/html-webpack-plugin
Wed, 18 Jan 2023 09:38:00 GMT
The html-webpack-plugin works without configuration. It's a great addition to the ⚙️ webpack-config-plugins. If you have multiple webpack entry points, they will all be included with script tags in ...
Carol Prives
Wed, 12 May 2021 22:31:00 GMT
Mutation of the p53 tumor suppressor gene is the most frequent lesion detected in cancer. Consequently, understanding the structure and function of the normal p53 protein and how it differs from the ...
New treatment for agressive prostate cancer shows promise
Thu, 03 Oct 2024 17:00:00 GMT
"Then, when we added loss of the p53 oncogene, the mice developed bona fide invasive prostate cancer. “It will be an addition to the field to have a genetically engineered mouse model that parallels ...
The transcription factors TFE3 and TFEB amplify p53 dependent transcriptional programs in response to DNA damage
Wed, 05 Dec 2018 16:00:00 GMT
Here we demonstrate that DNA damage activates TFE3 and TFEB in a p53 and mTORC1 dependent manner. RNA-Seq analysis of TFEB/TFE3 double-knockout cells exposed to etoposide reveals a profound ...