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    p53 polymorphisms: cancer implications

     Thu, 30 May 2024 02:59:00 GMT
    p53 lies at the hub of a vast signalling network. Polymorphisms in upstream activators, repressors or downstream effectors of p53 might individually modulate cancer risk or interact with ...

    jantimon/html-webpack-plugin

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    p53 : The Most Frequently Altered Gene in Human Cancers

     Sat, 25 Nov 2023 13:58:00 GMT
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    Zinc shapes the folding landscape of p53 and establishes a pathway for reactivating structurally diverse cancer mutants

     Tue, 01 Dec 2020 16:00:00 GMT
    Missense mutations in the p53 DNA-binding domain (DBD) contribute to half of new cancer cases annually. Here we present a thermodynamic model that quantifies and links the major pathways by which ...

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     Tue, 04 Jul 2023 03:54:00 GMT
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    Mutant mice lacking alternatively spliced p53 isoforms unveil Ackr4 as a male-specific prognostic factor in Myc-driven B-cell lymphomas

     Tue, 01 Oct 2024 17:00:00 GMT
    This important study using engineered mouse models provides a first and compelling demonstration of a pathogenic phenotype associated with lack of expression of p53AS, an isoform of the p53 protein ...