Actualités PDGFRA
An overview on molecular biology of KIT/PDGFRA wild type (WT) gastrointestinal stromal tumours (GIST)
Wed, 24 Apr 2013 04:59:00 GMT
Background About 85% of paediatric gastrointestinal stromal tumours (GISTs) and about 10–15% of adult GISTs do not harbour any mutations in the KIT and PDGFRA genes and are defined as KIT/PDGFRA wild ...
A PDGFRA promoter polymorphism, which disrupts the binding of ZNF148, is associated with primitive neuroectodermal tumours and ependymomas
Fri, 08 Sep 2023 06:07:00 GMT
1 Department of Genetics and Pathology, Uppsala University, Rudbeck Laboratory, 751 85 Uppsala, Sweden 2 Department of Neuroscience, Neurology, Uppsala University, University Hospital, 751 85 Uppsala, ...
Defining cell type-specific immune responses in a mouse model of allergic contact dermatitis by single-cell transcriptomics
Sun, 24 Mar 2024 17:00:00 GMT
(A) tSNE plots showing cell distribution of the Pdgfra + dermal fibroblasts after re-clustering. (B) Bubble plots showing the expression of marker genes for each dFB cell cluster. Abbreviations: AP, ...
The Lateral Ganglionic Eminence Does Not Generate Cortical Oligodendrocytes
Fri, 08 Mar 2024 01:09:00 GMT
(A) In situ hybridization showing Pdgfra expression from E13.5 to P0. Arrowheads indicated the Pdgfra + cell migration stream from the MGE/AEP to the cortex. (B) Scheme of the IS reporter lines. (C) ...
DIPG in Children – What Can We Learn from the Past?
Mon, 19 Oct 2015 17:00:00 GMT
At the time of diagnosis, whenever available, biopsy specimens of DIPG are suggested to be tested for Histone K27M mutations (H3.3 and 3.1) along with routine WHO histological grading and other ...
Eosinophilic myocarditis as a first presentation of eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome)
Tue, 05 Mar 2024 15:32:00 GMT
He was treated with high dose glucocorticoids and made a rapid recovery. Testing for FIP1L1-PDGFRA and other BCR-ABL1 mutations was negative. Ultimately, he was diagnosed with eosinophilic ...
A Study to Evaluate the Safety and Tolerability of DCC-2618 in Patients with Advanced Malignancies
Sat, 10 Feb 2018 11:43:00 GMT
Contact the study team to discuss study eligibility and potential participation. GIST patients must have a KIT or PDGFRA mutation and must have progressed on or had an intolerability to at least 1 ...
Prognostic model development and molecular subtypes identification in bladder urothelial cancer
Wed, 28 Feb 2024 13:59:00 GMT
As a result, a new risk signature was created that includes four genes associated with OS (RBPMS, CRYAB, P4HB, and PDGFRA). The researchers found two separate groups, C1 and C2, that showed ...
Prx1 Expressing Cells Are Required for Periodontal Regeneration of the Mouse Incisor
Mon, 20 May 2019 17:00:00 GMT
We investigated and compared the expression of the genes in the following categories between GFP+ and GFP- cells: (A) progenitor cell and stem cell markers: Cd44, Pdgfra, Smo, and Col2a1; (B) Wnt ...
Fate Mapping of Sca1 + Cardiac Progenitor Cells in the Adult Mouse Heart
Sun, 16 Dec 2018 16:00:00 GMT
State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Institute of Biochemistry and Cell Biology, Shanghai Institutes for ...